Fioricet is considered a "combination medicine" because it combines the benefits of many drugs into a single tablet. Fioricet contains a combination of acetaminophen, butalbital, and caffeine.

Although caffeine and acetaminophen are both excellent pain medications, butalbital also causes relaxation, which may help alleviate the tense muscles that contribute to tension headaches. This medicine is very effective for the treatment of severe tension headaches that may cause significant disruption to a person's daily life when used on an as-needed basis.